We generate Xaperones that facilitate the crystallization of your proteins of interest. We identify Xaperones that stabilize unique therapeutic conformations of your targets
Chaperon or Chaperone n.
- Social: an adult who supervises one or more unmarried men or women during social occasions
- Headgear: a form of hood or versatile hat worn in Western Europe in the Middle Ages
- Protein: a protein that assists the non-covalent folding/unfolding in molecular biology
- X-ray crystallography: a protein that assists another protein to crystallize
Xaperone
XaperonesTM are crystallization chaperones derived from camelid heavy chain only antibodies that:
- bind cryptic epitopes and lock proteins in unique native conformations
- increase the stability of soluble proteins and solubilized membrane proteins
- reduce the complexity in conformationally rich proteins
- increase the polar surface enabling the growth of diffracting crystals
- sequester aggregative or polymerizing surfaces
- allow to affinity-trap active protein
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